9.3 Endothelial progenitor cells and vasculogenic responses to therapy in children with primary systemic vasculitis
نویسندگان
چکیده
Materials and methods 20 children (median age 10.6 years (1–16.6); 10 males) with PSV at various stages of disease activity were studied. PSV was classified as: polyarteritis nodosa (n = 10); Wegener's granulomatosis (n = 6); Kawasaki disease (n = 2); Behçet's disease (n = 1) and unclassified (n = 1). EPCs were detected using flow cytometry and defined as cells triple-positive for CD34, CD133, and VEGFR2. Growth factors were measured using ELISA in serum (VEGF) or platelet-poor plasma (Angiopoietin-1, Angiopoietin-2). Disease activity was assessed using a modified BVAS scoring system and evaluation of circulating endothelial cells (CECs) [1].
منابع مشابه
Impaired function of endothelial progenitor cells in children with primary systemic vasculitis
INTRODUCTION Previously, we demonstrated that children with active systemic vasculitis (SV) have higher circulating CD34 + CD133 + KDR+ endothelial progenitor cells (EPC); the function of these EPCs, and their relationship with disease activity in vasculitis remains largely unexplored. We hypothesized that although EPC numbers are higher, EPC function is impaired in active SV of the young. The ...
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